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#hepatitis

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"The [Division of #Viral #Hepatitis] Laboratory Branch had the highest degree of viral hepatitis expertise of any #PublicHealth laboratory in the world," wrote Scott Becker, the assn's CEO. "Their loss eliminated critical national testing services that do not exist anywhere else within the #HHS agencies."

As of April 16, the assn had not received a response from #RFKJr, Becker said.

#Trump#Musk#DOGE
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2 days after the lab's scientists received their reduction in force emails, #HHS Secy #RFKJr acknowledged that ~⅕ of the cuts at HHS were made *unintentionally* & some people would be offered their jobs back.
On April 4, the Assn of #PublicHealth Laboratories sent a letter to RFKJr urging HHS to reinstate all personnel in the Division of #Viral #Hepatitis & at the Division of #STD Prevention, another lab at the #CDC that was shuttered.

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…Although 4 new samples have already arrived at the lab & 3 more were waiting in #Florida to be sent, none have been tested by the #CDC. Epidemiologists still at the CDC have been trying to find another place that can do the tests but have been unsuccessful….

…w/o the CDC's scientists to test the genetic material, it will be harder for epidemiologists to confirm whether people w/ #hepatitis C were infected in the same doctor's office or somewhere else where the #virus could still be spreading….

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The email said their duties were "identified as either unnecessary or virtually identical to duties being performed elsewhere in the agency." But the #genetic #tracing that the #CDC's lab performs is not conducted by any lab in the #UnitedStates or the #world….

While it remains shuttered, ongoing investigations of current #hepatitis #outbreaks have been stalled, not just in #Florida, but also in #Oregon, #Pennsylvania, #Massachusetts, #NewMexico, #Wisconsin, #WestVirginia & #Georgia….

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But on April 1, the #outbreak investigation was brought to a halt. All 27 of the lab's scientists received an email from the #HHS informing them that they were losing their #jobs. Like thousands of other employees who received similar emails that day, the scientists were told they would be placed on administrative leave until June 2, after which they would no longer work for the #CDC.

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The scientists at the lab knew what they were doing. Quickly, they analyzed the blood from #Florida using their custom software & found that 9 cases were genetically linked to the same pain clinic, where it was later discovered that a doctor was improperly reusing injection vials. By March, ofcls in FL had restricted the doctor's #medical license to limit the spread of the #virus & packaged new patient samples to send to the #CDC for testing…

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The #hepatitis C #virus, which is spread through contact w/infected blood & can lead to #deadly liver #cancer, is notoriously hard to identify. But if anyone could understand what was #happening in FL, it would be the Division of #ViralHepatitis in the #CDC's HQ.
Using samples from the lab's collection of nearly 1M frozen specimens, scientists helped make the initial discovery of the #HepatitisC virus in the 1980s. In 2020, that #research was awarded the #NobelPrize in #Medicine.
#Trump #science

In the middle of a #hepatitis #outbreak, #CDC shutters the one lab that could help

After people started testing positive for #HepatitisC in a coastal #Florida town in December, state ofcls collected blood from patients, wrapped their specimens in dry ice & mailed them straight to the CDC in ATL, GA.

#Trump #RFKJr #Musk #DOGE #cuts #idiocracy #kakistocracy #law #USpol #science #medicine #disease
npr.org/2025/04/16/nx-s1-53551

STIs are increasing in Australia. Can anything lower these rates?
By Sam Nichols

Sexual transmitted infections have continued to grow across Australia over the last three decades, with chlamydia, gonorrhoea and syphilis spiking in New South Wales alone. The reasons why are complex, experts say.

abc.net.au/news/2025-04-19/sti

ABC News · STIs are increasing in Australia. Can anything lower these rates?Por Sam Nichols

#Hepatitis #Covid

Remember the cases of pediatric fulminant hepatitis after Omicron ran through? Hypothesized to be associated with AAV infection?

Röttele et al. find SARS2 antigens in ACE2-expressing cells, in the areas of significant liver pathology, and conject an "immune-mediated postacute sequel to COVID-19".

#CDC Centers for Disease Control & Prevention sites datasets removed as of 1/31/25 . Not immediately clear what day they were removed: the Youth Risk Behavior Survey; AtlasPlus, which housed #HIV #AIDS, #Hepatitis and #STD information; #contraception page for #healthcare providers; page on ending #gender based #violence; Evidence supporting recommendations for #HPV vaccination harmonization across genders, ages 22 -26 yrs; #Heartdisease death rates by gender, by county axios.com/2025/01/31/health-cd

Axios · HIV, transgender care and other federal websites go darkPor April Rubin

A fascinating paper. I tried to explore the relationship between COVID and NOVHEP (with far more crude methods) when NOVHEP appeared in 2022 - see below for one of my threads.

I wondered if the Delta variant was a potential cause of NOVHEP, as the geographical distribution correlated better with case rates in the Delta period (Jun-Nov 2021).

#COVID19 #Delta #NOVHEP #Hepatitis
bmjpaedsopen.bmj.com/content/8
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BMJ Paediatrics OpenAcute hepatitis of unknown aetiology in children: evidence for and against causal relationships with SARS-CoV-2, HAdv and AAV2Background The cause of acute paediatric hepatitis of unknown aetiology (2022) has not been established despite extensive investigation.Objective To summarise the evidence for and against a causal role for human adenovirus (HAdv), adeno-associated virus 2 (AAV-2) and SARS-CoV-2 in outbreaks of paediatric hepatitis in 2022.Methods We appraised and summarised relevant evidence for each of the Bradford Hill criteria for causality using quantitative (statistical modelling) and qualitative (narrative coherence) approaches. Each team member scored the evidence base for each criterion separately for HAdv, AAV-2 and SARS-CoV-2; differences were resolved by discussion. We additionally examined criteria of strength and temporality by examining the lagged association between SARS-CoV-2 positivity, respiratory HAdv positivity, positive faecal HAdv specimens and excess A&E attendances in 1–4 years for liver conditions in England.Results Assessing criteria using the published literature and our modelling: for HAdv three Bradford Hill criteria (strength, consistency and temporality) were partially met; and five criteria (consistency, coherence, experimental manipulation, analogy and temporality) were minimally met. For AAV-2, the strength of association criterion was fully met, five criteria (consistency, temporality, specificity, biological gradient and plausibility) were partially met and three (coherence, analogy and experimental manipulation) were minimally met. For SARS-CoV-2, five criteria (strength of association, plausibility, temporality, coherence and analogy) were fully met; one (consistency) was partially met and three (specificity, biological gradient and experimental manipulation) were minimally met.Conclusion Based on the Bradford Hill criteria and modelling, HAdv alone is unlikely to be the cause of the recent increase in hepatitis in children. The causal link between SARS-CoV-2, and to a lesser degree AAV-2, appears substantially stronger but remains unproven. Hepatitis is a known complication of multisystem inflammatory syndrome in children following COVID-19, and SARS-CoV-2 has been linked to increased susceptibility to infection post-COVID-19, which may suggest complex causal pathways including a possible interaction with AAV-2 infection/reactivation in hosts that are genetically susceptible or sensitised to infection.

Starb Beethoven an den Folgen von #Hepatitis-B? Dem gehen die HZI-Forscher:innen Melanie Brinkmann & Thomas Pietschmann @TWINCORE in der 2. #InFact-Adventsfolge nach & nehmen Euch mit auf eine spannende medizinische Spurensuche. infacthzi.podigee.io/20-beetho
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